Elevated levels of HMGB1 and NLRP3 were implicated in the induction of the trigeminal system, with NLRP3 levels showed a moderate positive correlation with headache severity, length of hospitalization, and headache duration, while HMGB1 levels were positively correlated with headache severity (Bolay et al., 2021). The gene discussed is NLRP3; the disease is Headache.