In alcoholic liver disease, HMGB1 translocates from the nucleus to the cytoplasm in hepatocytes, increasing apoptosis signal-regulating kinase 1-positive hepatocytes, passive HMGB1 release, and NLRP3 inflammasome activation, promoting inflammation and hepatic fibrosis (Adjei-Mosi et al., 2023). This evidence concerns the gene HMGB1 and alcoholic liver diseases.