HMGB1 also plays a crucial role in aseptic inflammation by activating the NLRP3 inflammasome, inducing IL-1β secretion and sepsis, and recruiting neutrophils and eosinophils, resulting in inflammatory infiltration and tissue damage (Jessop and Holian, 2015; Noguchi et al., 2021). The gene discussed is HMGB1; the disease is Sepsis.