AGER and neoplasm: These receptors mainly include classical PRRs such as TLR4 and RAGE, as well as non-canonical receptors like TIM-3 (Tang and Lotze, 2012) and CXCR4 (Pirani et al., 2024), which are differentially expressed across immune cell subsets and pathological states, thereby contributing to distinct immunological outcomes in processes such as inflammation, tumor progression, and tissue repair.