Increased activity in the NF-KB inflammatory pathway leads to an increase in the secretion of ILs 1, 6, and 8, tumor necrosis factor (TNF) alpha, intracellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule (VCAM), ultimately resulting in a higher incidence of thrombosis [74–79]. The gene discussed is TNF; the disease is deep vein thrombosis.