A pan-cancer expression analysis revealed that SH3BP1 is highly expressed in ten cancer types: Cervical Squamous Cell Carcinoma and Intracervical Adenocarcinoma (CESC), Colon Adenocarcinoma (COAD), Renal Clear Cell Carcinoma (KIRC), Lung Squamous Cell Carcinoma (LUSC), Ovarian plasma cystadenocarcinoma (OV), pancreatic adenocarcinoma (PAAD), rectal adenocarcinoma (READ), gastric adenocarcinoma (STAD), testicular germ cell tumor (TGCT), and uterine sarcoma (UCS). Here, SH3BP1 is linked to pancreatic adenocarcinoma.