For example, Brannon et al. (2014) investigated the genomic differences between primary and metastatic colorectal cancer, while Schubert et al. (2020) focused on the significance of MSH6 and MUTYH genes in familial colorectal cancer, and Lee-Six et al. (2019) detailed the mutations in the epithelial cells of normal colorectal cancer. Here, MSH6 is linked to metastatic colorectal cancer.