In leukemia, the Cobbl1/SH3BP1/PACSIN2 axis promotes drug resistance and progression of chronic myeloid leukemia by regulating Rac1 activity, while the expression level of SH3BP1 is inversely correlated with the prognosis of acute myeloid leukemia (Park et al., 2022; Yang et al., 2024). Here, SH3BP1 is linked to acute myeloid leukemia.