SH3BP1 and colorectal cancer: As shown in Figure 7A, the proliferative capacity of the colorectal cancer cells (HCT116 and RKO) was significantly reduced in the SH3BP1 knockdown group (si-SH3BP1-1, si-SH3BP1-2) compared to the si-NC group, as demonstrated by a cell viability assay (CCK8).