In addition, Tao (Tao et al., 2016) and others also found that SH3BP1/Rac/Wave2 can promote the production of vascular endothelial growth factor (VEGF) in hepatoma cells and induce the metastasis of liver cancer cells; Cicchetti (Cicchetti et al., 1995) and others also found that SH3BP1 resists cell folding by acting on the downstream target Rac. The gene discussed is WASF2; the disease is hepatocellular carcinoma.