TP53 and colorectal cancer: Whole genome sequencing can also detect the whole genome of tumors, such as gallbladder cancer (Okawa et al., 2023), prostate cancer (Liang et al., 2020), etc. Whole genome sequencing can also be used to sequence colorectal cancer, which can identify oncogenic mutated genes and signaling pathways, including oncogenes such as APC, tumor protein P53 (Tp53), and KRAS proto-oncogenes, and oncogenic pathways such as Wnt, P53, and phosphoinositide 3-kinase (Teng et al., 2018).