SH3BP1 and neoplasm: In addition, SH3BP1 acts as a GTPase-activating protein of Cdc42 and forms a complex with filamentous protein plus capsid protein (CapZ) to restrict Cdc42 signaling to regulate actin-driven cell membrane remodeling and intercellular junctions, maintains the morphology, stability, and connectivity of epithelial cells, and may be involved in epithelial-mesenchymal transition (EMT) (Elbediwy et al., 2012; Kang et al., 2020), and is thus considered an important regulator of cancer cell metastasis, which may promote the value-added migration of tumor cells.