Comparing the expression of SH3BP1, CPA6, ZNF888, and NKRD16 in COAD and READ tumor and normal tissues revealed that SH3BP1 expression increased in COAD and READ and was more prevalent in tumor tissues than in the other susceptibility genes obtained by whole-genome sequencing (Figures 5B,C). The gene discussed is SH3BP1; the disease is neoplasm.