The diagnosis of APS relies on persistent moderate-to-high titers of “consensus” antiphospholipid antibodies (aPLs), including lupus anticoagulant (LA), anticardiolipin (aCL) IgG/IgM, and anti-β2-glycoprotein I (aβ2GPI) IgG/IgM (1). This evidence concerns the gene CD40LG and autoimmune polyendocrinopathy.