reported that asymptomatic carriers of isolated positive aβ2GPI IgA (n=244) had significantly higher incidence of APS-events and arterial thrombosis than seronegative controls (n=221) in 5-year follow-up, with ischemic stroke emerging as the predominant arterial event in patients with aB2GP1 IgA (10). This evidence concerns the gene CD79A and autoimmune polyendocrinopathy.