One of the biggest series of APS data from three different cohorts (Lupus in Minorities, LUMINA, the John Hopkins SLE cohort) showed that more than two-thirds of patients with isolated positive aβ2GPI IgA had APS clinical manifestations, and isolated positive aβ2GPI IgA was significantly associated with increased risk of arterial thrombosis and all thrombosis, even after adjusting for other risk factors of thrombosis (8, 9). This evidence concerns the gene CD79A and autoimmune polyendocrinopathy.