Evidence indicates that sustained physiological stress intensifies the immune response, such as hypothalamic-pituitary-adrenocortical activation.68, 69, 70, 71 This leads to a decrease in β2 adrenergic and glucocorticoid receptors, which reduces the responsiveness to asthma medication and, in turn, increases the risk of exacerbation.70 Here, NR3C1 is linked to asthma.