GAD2 and acquired angioedema: In the context of positive GAD65, the low rates of seizure freedom despite immunotherapy suggest that the risk of further seizures over the next 10 years is very high which is similar to the timespan and the disease course of our patient fulfilling the conceptual and practical definitions of epilepsy, in addition to the definition of AAE evident by high titer serum GAD65 antibodies [5,8,9].