The rs6967330 variant in cadherin-related family member 3 (CDHR3), which encodes a receptor for human rhinovirus C, was also analyzed, because studies on CDHR3 in adults are limited, despite its identification as a risk factor for asthma exacerbation in children5,22,23 similarly to GSDMB/ORMDL3. Here, ORMDL3 is linked to asthma.