GSDMB and asthma: Since the first genome-wide association study in 2007,4 the 17q21 locus, which includes gasdermin B (GSDMB) and orosomucoid-like 3 (ORMDL3), has emerged as the most significant susceptibility locus in childhood and early-onset asthma, independent of atopic predisposition.5, 6, 7, 8 Although its association with pediatric asthma is well established, this locus has also been reported to be linked to disease severity in adult asthma.9