Variants in GSDMB/ORMDL3 lead to increased expression of GSDMB and ORMDL3 in immune cells4,11,12 and airway epithelial cells (AECs)9 and are linked not only to asthma susceptibility but also to disease severity and exacerbation risks in both children6,13 and adults,9,10 suggesting a broader role in asthma pathophysiology across different age groups. This evidence concerns the gene ORMDL3 and asthma.