Notably, recent studies have shown a stronger association between the rs7216389 variant and asthma in nonallergic condition compared with allergic condition,9,17,21 indicating that the 17q21 region, containing GSDMB/ORMDL3, plays a key role in the pathophysiology of type 2–low asthma, particularly nonallergic asthma. Here, ORMDL3 is linked to asthma.