JKAP knockdown in Th17 cells increased RA-FLS proliferation (p < 0.01) (Figure 5A), reduced apoptosis (p < 0.01) (Figures 5B and 5D), enhanced invasion (p < 0.01) (Figures 5C and 5E), and stimulated the release of inflammatory cytokines, including IL-6 (p < 0.01) (Figure 5F), IL-8 (p < 0.01) (Figure 5G), CCL2 (p < 0.05) (Figure 5H), and MMP3 (p < 0.01) (Figure 5I). This evidence concerns the gene MMP3 and rheumatoid arthritis.