Direct knockdown of JKAP using lentivirus decreased JKAP expression (p < 0.01) (Figures S2A–S2C) and increased the expression of phosphorylated AKT (p-AKT) (p < 0.01) (Figures 4A and 4B) and phosphorylated ERK (p-ERK) (p < 0.01) (Figures 4A and 4C) in RA CD4+ T cells. The gene discussed is DUSP22; the disease is rheumatoid arthritis.