CD4 and rheumatoid arthritis: ,26,27,28 In this study, JKAP-knockdown BMSC-exosomes increased the expression of phosphorylated AKT (p-AKT) (p < 0.05) (Figures 2L and 2M) and phosphorylated ERK (p-ERK) (p < 0.05) (Figures 2L and 2N) in RA CD4+ T cells, but did not affect the expression of phosphorylated p38 (p-p38) (p > 0.05) (Figures 2L and 2O), compared to Scramble BMSC-exosomes.