Whereas circPDE3B indirectly inhibits ferroptosis and promotes ESCC development through the HNRNPK/SLC7A11 and miR-516b-5p/CBS axis55; circ_000014/miR-527 reduces the sensitivity of oral squamous cell carcinoma cells to ferroptosis and increases their resistance to cisplatin (DDP) by regulating SLC7A11 expression.56 Here, SLC7A11 is linked to esophageal squamous cell carcinoma.