,108 On the other hand, Rab8a and Rab10 with enhanced phosphorylation catalyzed by PD-related LRRK2 mutants showed increased binding with effector proteins (RILPL1 and RILPl2), which inhibit protein trafficking and hinder ciliogenesis and neuronal cell development.109. The gene discussed is RILPL2; the disease is Parkinson disease.