While DKK1 is downregulated in BRAF-mutant organoids and in BRAF-mutant CRCs in larger datasets (such as the CRC TCGA dataset30 and the colon cancer dataset from Marisa et al.31), this does not necessarily imply that BRAFV600E directly causes this downregulation. This evidence concerns the gene DKK1 and malignant colon neoplasm.