The MC-38 adenocarcinoma cell line was transplanted into wild-type (Pdcd1+/+/Crbn+/+), Pdcd1+/+/CrbnI391V/I391V, and Pdcd1SD/SD/CrbnI391V/I391V mice to examine the effects of the oral administration of IBR on endogenous PD-1 degradation in vivo (Figure 7A). This evidence concerns the gene CRBN and adenocarcinoma.