Proliferation of GL-261 was also suppressed in the Pdcd1SD/SD/CrbnI391V/I391V mice with IBR oral administration compared to non-treated Pdcd1SD/SD/CrbnI391V/I391V and IBR-treated Pdcd1+/+/CrbnI391V/I391V mice (Figure S9), suggesting the growth of highly immunogenic tumor cell lines might be inhibited in a similar method. Here, PDCD1 is linked to neoplasm.