CD14 and rheumatoid arthritis: While patients with long-standing RA do not show increased frequencies of CD14+ DC3s compared to HDs, patients with ERA had almost twice the amount of CD14+ DC3s compared to HDs (0.27% vs. 0.15% of PBMCs) and significantly increased frequencies compared to long-standing RA (0.11% of PMBCs) (Figure 1A).