TOP2A and hepatocellular carcinoma: Elevated mRNA abundances of Dtl, Top2a, Cdc6, and Mki67 are associated with highly proliferative phenotypes in HCC, a disease that can emerge as a long-term consequence of liver steatosis.48,50,59–63 We detected increased mRNA abundance of Dtl, Top2a, Cdc6, and Mki67 in liver before development of macrovesicular steatosis in hepAGT +/+ mice, suggesting that cell proliferation precedes WD-induced liver pathology.