We further used immunofluorescence (IF) to double stain for CD16/Iba1 (pro-inflammatory) and CD206/Iba1 (anti-inflammatory), and the results (Figure 4I) demonstrated that CAG could inhibit pro-inflammatory microglia/macrophages and promote the polarization of anti-inflammatory microglia/macrophages following radiation-induced brain injury in tumor-bearing mice. This evidence concerns the gene AIF1 and neoplasm.