Blood tests indicated D-dimer >20 mg/L, erythrocyte sedimentation rate 78 mm/h, antinuclear antibody 333.10 AU/mL, weakly positive anti-SSA/Ro52 and anti-SSA/Ro60 antibodies, complement C3 1.81 g/L, and C4 0.83 g/L, anti-double-stranded DNA antibodies were negative, the lupus screening ratio was normal, anticardiolipin antibodies were normal, and no other blood tests were significantly abnormal. The gene discussed is TRIM21; the disease is systemic lupus erythematosus.