In depression and CDAHFD-fed mice, hepatic steatosis was aggravated by activating the HPA axis (104) In clinical practice, in patients with insulin-dependent hyperglycemia and concomitant hyperprolactinemia, liver steatosis was reversed and triglyceride levels returned to normal or near-normal levels after treatment with the ACTH receptor antagonist mifepristone (105). This evidence concerns the gene MC2R and Hepatic steatosis.