SERS imaging based on antibody-conjugated immunoassays is promisingto measure biomolecule distribution and internalization in cells,, and has been widely used to detect a variety of biomolecules.−,  By modifying GNRs with 4-mercaptobenzoic acid (4-MBA) and an antibody,Xiao et al. revealed the spatial distribution and the dynamic changein epidermal growth factor receptor (EGFR) levels in living breastcancer cells. They detected an overexpressedreceptor, tyrosine kinase, in human cancer cells. The gene discussed is EGFR; the disease is cancer.