ABO and graft versus host disease: Among them, non-immune factors, such as fever, bleeding, spleen enlargement, disseminated intravascular coagulation (DIC), graft-versus-host disease (GVHD, drugs( such as amphotericin, vancomycin, etc.), longer platelet storage time and poor platelet quality, are the dominant ones, accounting for approximately 80% [7–9], while the remaining 20% are caused by immune factors, include human leukocyte antigen (HLA) antibodies, platelet alloantibodies, ABO antibodies and drug-dependent autoantibody [10, 11].