Furthermore, some studies have found that TIMP1 in serum can be used as a biomarker for the prediction and diagnosis of malignant tumors such as colorectal cancer (33), gastric cancer (34), oropharyngeal cancer (35), etc., which fully indicates that TIMP1 has potential clinical practice value and guiding role in malignant tumors. The gene discussed is TIMP1; the disease is oropharynx cancer.