We demonstrated that the complex [Ru­(trans-4-(trifluoromethyl)­cinnam)­(dppb)­(bipy)]­PF6 effectivelyinhibited the proliferation of melanoma cells with either an activating N-Ras mutation or a TP53 inactivation mutation.Therefore, in this study, we aimed to evaluate the antitumor potentialof complex [Ru­(3,4-cinnam)­(dppb)­(bipy)]­PF6, named CINNAM,against nonsmall cell lung cancer cells A549 (TP53 wild type; K-Ras mutated) and H1299 (TP53 mutated; N-Ras mutated). The gene discussed is TP53; the disease is melanoma.