ADIPOQ and systemic sclerosis: Applying the sensitivity analyses to account for horizontal pleiotropy also did not indicate any adiponectin to SSc risk causal effect (weighted median: OR (95% CI) = 0.89 (0.44 to 1.82), p = 0.76; simple median: OR (95% CI) = 1.09 (0.46 to 2.56), p = 0.84; MR-Egger: OR (95% CI) = 0.45 (0.18 to 1.13), p = 0.08, pintercept = 0.01) (Figure 3).