The main MR analysis, using the IVW method, provided evidence for a causal association between a genetic liability to SSc and lower circulating adiponectin levels in the overall SSc group (dcSSc and lcSSc combined) (ß (95% CI) = −0.027 (−0.04 to −0.02), p = 6.8E-06) (Figure 5). This evidence concerns the gene ADIPOQ and systemic sclerosis.