For example, in the breast tumor microenvironment, ECM stiffness has been linked to increased cell invasiveness, supporting metastasis by triggering EMT and activating pathways such as twist family BHLH transcription factor 1 (TWIST1)‐ GTPase‐activating protein SH3 domain‐binding protein 2 (G3BP2) and ephrin type‐A receptor 2 (EPHA2)/LYN proto‐oncogene, Src family tyrosine kinase (LYN)/TWIST1 [37, 38]. Here, TWIST1 is linked to breast neoplasm.