Elevated stiffness in the tumor microenvironment (TME) has been shown to facilitate malignancy by promoting cancer cell invasiveness, enhancing immune cell infiltration, and inducing epithelial mesenchymal transition (EMT) through signaling pathways such as transforming growth factor‐beta (TGF‐β) [31, 32, 33]. This evidence concerns the gene TGFB1 and neoplasm.