LOXL2 and pulmonary fibrosis: In fibrotic diseases, such as pulmonary fibrosis, persistent TGF‐β1 signaling activates α‐smooth muscle actin positive (α‐SMA+) myofibroblasts, which deposit stiff collagen I. LOXL2‐mediated collagen crosslinking generates irreversible fibrils resistant to MMP cleavage.