Congenital immunodeficiencies with candidiasis, T lymphocyte dysfunction, and IL-17 deficiency have been described in the context of pathogenic variants in genes such as STAT3, CARD9, DOCK8, ACT1, IL-17RC, IL-17RA, and IL-17F—where fluconazole is the first-line treatment [9]. Here, CARD9 is linked to Candidiasis, Invasive.