Our previous research revealed that virgin camellia seed oil improved high-fat diet-induced metabolic disorders in rats by activating adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) and fatty acid oxidation enzymes, while suppressing lipid synthesis via downregulating sterol-regulatory element binding protein 2 (SREBP2) and its target genes (Zhu et al., 2023). This evidence concerns the gene SREBF2 and metabolic disease.