CRH and neuropathic pain: However, an earlier study showed that optogenetic silencing of CeA’s CRF neurons decreased emotional affective responses in acute and chronic phases of the same neuropathic pain model (SNL) (Mazzitelli et al. 2022), suggesting that at the chronic phase of injury, the CRF neuronal excitability seems to be not necessary for the maintenance of injury associated mechanical hypersensitivity and emotional affective behaviors warranting an alternate explanation.