Now there is a 5 year survival rate of 48–64 % for germ cell tumors that meet poor prognosis criteria, which includes one of the following: mediastinal primary tumors, nonpulmonary visceral metastases, AFP levels greater than 10,000 ng/mL, or b-hCG levels greater than 50,000 IU/L.15 The gene discussed is AFP; the disease is testicular germ cell tumor.