,19 While UBE2J2 has been implicated in human leukocyte antigen (HLA) degradation via binding to the E3 TMEM129 (transmembrane protein 129)20,21; degradation of squalene monooxygenase (SQLE) via binding with the E3, MARCH6 (membrane-associated ring-CH-type finger 6), to maintain homeostasis of cholesterol metabolism homeostasis22; regulating Wnt cargo receptor protein, Evi, through binding with the E3, CGRRF1 (cell growth regulator with ring finger domain 1)23; and promoting epithelial-stromal transformation and invasion of hepatocellular carcinoma in vitro.24 This evidence concerns the gene SQLE and hepatocellular carcinoma.