A diagnosis of PC can be established in an affected individual either by observing the clinical triad of dystrophic nails, plantar keratoderma, and plantar pain, or by identifying a heterozygous pathogenic mutation within one of the five keratin genes associated with PC: KRT6A, KRT6B, KRT6C, KRT16, and KRT17 [4]. This evidence concerns the gene KRT16 and pachyonychia congenita.