Lactate can influence immune cell polarization, as observed in tumor immunity, where it promotes the M2 polarization of tumor‐associated macrophages (TAMs) through pathways such as ERK and STAT3 activation.[36, 37] In this context, lactate not only serves as an energy source but also directly affects gene expression through lactylation, a posttranslational modification of histones.[21] To further strengthen the specificity of the effects of lactate, we included additional control groups treated with D‐lactate (D‐Lac), an inactive stereoisomer. Here, STAT3 is linked to neoplasm.