Interestingly, the prognostic value of LAG‐3 expression in GC is heterogeneous; while some studies associate high LAG‐3 infiltration with an immunoevasive contexture and poorer outcomes in specific molecular subtypes (e.g., EBV‐positive or MLH1‐defective GC) [62], other research suggests it may correlate with improved survival, highlighting the complexity of its role [63, 64]. This evidence concerns the gene MLH1 and gastric cancer.