In addition to the regulation of angiogenesis, autocrine and paracrine VEGF/VEGFR signaling in tumor cells contributes to cancer cell proliferation, survival, induction of the epithelial‐mesenchymal transition, and metastasis.[27, 28] For example, autocrine expression of VEGF has been reported to play a role in hematopoietic malignancies by stimulating the growth and migration of leukemic cells.[29] We, therefore, decided to evaluate the efficacy of our designs on the proliferation of the acute myeloid leukemia cell line, U937, that is sensitive to VEGF. This evidence concerns the gene VEGFA and cancer.