By contrast, the pathogenesis of MS remains unclear; increased levels of myelin‐specific autoreactive T‐helper (Th)‐17 cells, along with IL‐17A and IL‐22 in the periphery and CNS, play a central role, with their activity reliant on an increased availability of IL‐1β [39, 46, 47, 48]. The gene discussed is IL1B; the disease is myeloid sarcoma.