■CV drugs with central nervous system (CNS) bioavailability carry the highest risk (disopyramide, quinidine, digoxin, clonidine, methyldopa, propranolol, reserpine)■Delirium was more common with calcium channel blockers than with renin–angiotensin system agents (∼40% higher) but less common than with beta‐blockers (∼20% lower)■Visual hallucinations have been reported with angiotensin‐converting enzyme (ACE) inhibitors in older patients, particularly those with a history of dementia or mild cognitive impairment. The gene discussed is REN; the disease is Cognitive impairment.