This retrospective study evaluated the effect of Sac/Val on BP, the urinary protein‐to‐creatinine ratio (UPCR), and the estimated glomerular filtration rate (eGFR) in 66 patients with hypertension and proteinuria (UPCR ≥ 0.15 g/g) who received renin–angiotensin system inhibitors at 1, 3, and 6 months. This evidence concerns the gene REN and hypertensive disorder.