The role of many of these genes in glioma development progression has already been reported [1p/19q co-deletion: (Ostrom et al. 2014), IDH1: (Network 2015), CDKN2A/B: (Komori 2022), PTEN: (Wemmert et al. 2005, Ni et al. 2022), EGFR: (Zhao et al. 2021)]. This evidence concerns the gene PTEN and glioma.