A binary logistic regression model was constructed, incorporating covariates demonstrating univariate significance (p < 0.05 for hypertension, diabetes mellitus, systolic blood pressure, diastolic blood pressure, blood urea nitrogen, serum creatinine, eGFR, uric acid, CCB, ACEI, ARB, plasma GAS5, and urinary GAS5). This evidence concerns the gene GAS5 and hypertensive disorder.