TGFB1 and Abnormal renal physiology: In contrast, marked clinical divergences were observed in cardiometabolic parameters: the fibrotic cohort exhibited significantly higher prevalence rates of diabetes mellitus (DM) and hypertension (p < 0.001), elevated systolic/diastolic blood pressure, administion of CCB/ACEI/ARB (p < 0.05), and exacerbated renal dysfunction biomarkers including blood urea nitrogen (BUN), serum creatinine, uric acid, TGF-β1 and reduced estimated glomerular filtration rate (eGFR) (p < 0.001 for all) (Table 1).