Especially, with GSEA (Gene Set Enrichment Analysis) sorting, it was revealed that VEGF-C upregulated several signal pathways, such as the SIGNALING BY THE B_CELL_ RECEPTOR_BCR (Supplementary Fig. 15b) and INITIAL_TRIGGERING_OF_COMPLEMENT (Supplementary Fig. 15c), et al. The increased infiltration of immune cells (CD11b+, CD68+, MHC II+, CD3+) into the tumor sites in the VEGF-C treatment group was demonstrated by IHC staining (Supplementary Fig. 15d, e). The gene discussed is VEGFC; the disease is neoplasm.