VEGFC and hepatocellular carcinoma: Additionally, we analyzed the relationships among TLSs, CCR7, VEGF-C in tumor tissues from clinical HCC patients treated with Anti-PD-1 immunotherapy based on publicly available datasets.30,31 These studies divided HCC patients into Non-responders and Responders to immunotherapy, and representative HE-stained images were shown in Supplementary Fig. 18a.