Therefore, in order to identify the complicated TME of HCC, we analyzed the expression of CCR7-related ligands based on the previous spatial transcriptomics analysis on the HCC patient dataset.28 The representative images of CCL21, CCL19 and Pecam1(CD31) as well as Lyve1 from Patient 1 and Patient 2 were presented (Fig. 3a–d). Here, CCR7 is linked to hepatocellular carcinoma.