In addition, the roles and underlying mechanisms of CCR7 and VEGF-C in HCC should be further validated by using the KO mice of CCR7 and VEGF-C, including investigating the effects of CCR7 and VEGF-C on tumor growth, metastasis, and the response to sorafenib and anti-PD-1 immunotherapy. This evidence concerns the gene VEGFC and hepatocellular carcinoma.