These findings suggested that VEGF-C induced lymphatic angiogenesis in HCC tumors (VEGF-C vs. LYVE1), then CCR7+ cells were introduced into the tumor through lymphatic vessels under the chemotactic influence of CCL21 (VEGF-C vs. CCL21, VEGF-C vs. CCR7, and CCL21 vs. CCR7). The gene discussed is CCR7; the disease is hepatocellular carcinoma.