AKT1 and hepatocellular carcinoma: Unfortunately, due to the emergence of resistance, an increasing number of patients fail to achieve long-term survival from sorafenib therapy.5,39 Prolonged exposure to sorafenib leads to the gradual transformation of HCC cells into a mesenchymal state and the acquisition of sorafenib resistance following EMT40,41 In vitro, we found that sorafenib significantly inhibited EMT in CCR7-KO cells, and the AKT and ERK signaling pathways were involved in this process.