To support these findings, we analyzed a published single-cell RNA-seq dataset from Chinese patients with primary liver cancer.25 The data shown that CCR7 was more widely and highly expressed in HCC epithelial cells, compared with other liver neoplastic diseases, for examples, intrahepatic cholangiocarcinoma (ICC), secondary liver cancer (SLC), combined hepatocellular and intrahepatic cholangiocarcinoma (CHC), adenosquamous carcinoma (ASC), hepatic hemangioma (HH) and sarcomatoid carcinoma (SAR) (Fig. 1f, g). Here, CCR7 is linked to cryohydrocytosis.