REG4 and familial pancreatic carcinoma: For example, REG4 is a postulated tumour marker for pancreatic adenocarcinoma,16 gastric and colorectal cancer,17 EpCAM is a well-known tumour marker associated with many cancers including colorectal, ovarian and breast cancers18 and REG1A has been recently associated with the development of pancreatic cancer.19