Four additional new epitopes targeted by T cells derived from related secretory pathways not specific to islet β cells (EHD1, EHD4, SDCBP, CDH1), and several new T1D epitopes derive from proteins with no known disease-related or autoimmune function (MYH9, MYL12B, LAMC2, COBL, FLNA, JAG1) (all detailed in Table S10). Here, COBL is linked to type 1 diabetes mellitus.