This peptide as well as the native non-modified peptide 146 were recognized by IFN-γ-secreting CD4 T cells in expanded PBMCs from a T1D donor (Figure S6), with both peptides showing tight binding to HLA-DR3 with IC50 of 270–300 nM (Figure S4A). The gene discussed is CD4; the disease is type 1 diabetes mellitus.