Among the 110 biallelic MCM8 variant carriers in the 200000 UK Biobank, 2 individuals (1.8%) were registered with CRC, 3 (2.7%) with colonic polyps, 4 (3.6%) with adenomas, 1 (0.9%) with female infertility, and 6 (5.5%) with hypothyroidism. Here, MCM8 is linked to female infertility.