MCM9 and rectal hyperplastic polyp: While no significant enrichment of biallelic MCM8 pLoF or predicted deleterious missense variants were observed for any of these phenotypes compared to controls, we did observe significant associations between biallelic MCM9 pLoF or predicted deleterious missense variants and colonic polyps (odds ratio [OR] 6.51, 95% confidence interval [CI] 1.24–34.11, p = 0.03), rectal polyps (OR 8.40, 95% CI 1.28–55.35, p = 0.03), and gastric cancer (OR 27.03, 95% CI 2.93–248.5, p = 0.004) (Table 2).