Among the 74 biallelic MCM9 variant carriers in the 200000 UK Biobank, 1 individual (1.4%) was registered with colorectal cancer (CRC), 3 (4%) with colonic polyps, 6 (8%) with adenomas, 1 (1.4%) with rectal polyps, and 2 (2.7%) with hypothyroidism. The gene discussed is MCM9; the disease is hypothyroidism.