MCM8 and hypogonadism: Although the prevalence of hypogonadism among monoallelic carriers in our case series (29% for MCM8, 22% for MCM9) appears higher than the global prevalence (e.g., 3.5% for POI84), the potential ascertainment bias in our study, as previously discussed, highlights the need for further research to more fully characterize the phenotype of monoallelic MCM8/MCM9 variant carriers.