TAF15 and lung adenocarcinoma: Additionally, Su et al. found that TIFIγ inhibits TAF15/TBPmediated IL-6 transcriptional activation, competing with TAF15 for TBP binding and modifying TAF15 through multiple monoubiquitinations [33], this process inhibits epithelial-mesenchymal transformation and metastasis in lung adenocarcinoma.