Notably, analysis of IGF2 expression across more than 1,000 cancer cell lines revealed that IGF2 is selectively and highly expressed in embryonal tumors, including Wilms tumor, hepatoblastoma, rhabdomyosarcoma, CIC–DUX4 sarcoma, and synovial sarcoma (Supplementary Fig. 1). Here, IGF2 is linked to embryonal neoplasm.