While the EPHA signaling pathway includes the genes encoding the receptor tyrosine kinases Ephrin1-8 (Epha1-8) and ligands Ephrin 1–5 (Efna1-5), this elevation in inferred signaling was mostly driven by expression changes in Epha4 and Epha7, which were significantly upregulated in glutamatergic neurons in AD compared to controls (EPHA4, logFC = 0.695, adjusted p-value = 0.000557; EPHA7, logFC = 0.386, adjusted p-value = 0.00468, Supplementary Table 1). Here, EPHA4 is linked to Alzheimer disease.