GLS and Alzheimer disease: When considering genes implicated in glutamate production rather than receptors, we found that the gene glutaminase (Gls) was significantly upregulated in glutamatergic neurons in 8-month-old 5xFAD mice and tissue samples from human AD brains (logFC = 0.0594, adjusted p-value = 4.79E-05, and logFC = 0.427, adjusted p-value = 4.49E-14, Supplementary Table 1).