Several predicted increased interactions were observed in both 5xFAD mice at 8 months of age and human AD, including between glutamate and AMPA-type glutamate receptors (Glu-Gria1, Glu-Gria2, Glu-Gria4), NMDA-type glutamate receptors (Glu-Grin2b and Glu-Grin1), kainite-type glutamate receptors (Glu-Grik2), metabotropic glutamate receptors (Glu-Grm1, Glu-Grm5, Glu-Grm8), and the neuronal adhesion molecules neurexin and neuroligin (Nrxn3-Nlgn1; Fig. 4E). This evidence concerns the gene NLGN1 and Alzheimer disease.