Notably, one of these transcription factors within the network, SRY-box transcription factor 11 (Sox11), has previously been implicated in controlling intrinsic neuronal excitability, with its expression being activity-regulated106, raising the possibility that this gene may play an important role in regulating the elevation of intrinsic neuronal excitability that occurs in AD. The gene discussed is SOX11; the disease is Alzheimer disease.