PTPRM and Alzheimer disease: For example, the receptor-type tyrosine-protein phosphatase mu (PTPRM) had higher predicted signaling in brains from people with AD but lower in 5xFAD mice, the glycoprotein prosaposin (PSAP) was higher in AD but lower in 5xFAD mice, and the growth factor platelet-derived growth factor (PDGF) was lower in AD and higher in 8-month-old 5xFAD mice relative to controls (Fig. S6B).