GRM1 and Alzheimer disease: While the glutamate receptor Grm1 was significantly upregulated in 5xFAD mice, this was not the case in AD (Supplementary Table 1), despite the NeuronChat results predicting increased signaling via Grm1. These observations suggest that perhaps in AD, elevations in the production of glutamate, rather than its receptors, may be driving increased signaling.