CASP8 and neoplasm: Since TRAIL-R2/FADD/pro-caspase-8 and cFLIP colocalize in intracellular membrane compartments even in the absence of TRAIL [69], cFLIPL downregulation in glutamine-dependent tumor cells could facilitate TRAIL-R2/DR5 aggregation and subsequent NF-kB activation, leading to IL-8 induction.