Interestingly, one of the proteins displaying the most statistically significant regulation was the tryptophanyl t-RNA synthetase WARS1, which was increased in children with Confirmed TB vs. Unlikely TB (log2FC = 0.39, BH adjusted p = 3.3 × 10–5) (Fig. 3b), and is linked to TB infection via multiple mechanisms20–22. This evidence concerns the gene WARS1 and tuberculosis.