,65 Additionally, HTRA1 shows strong colocalization with amyloid deposits in both the rTg-DI and rTg-D HEM models,29,36,39 and with amyloid deposits in human CAA cases.64, 65, 66 These observations have led to the theory that sequestration of HTRA1 in amyloid deposits reduces its proteolytic activity.64 The gene discussed is HTRA1; the disease is amyloidosis.