TGFB1 and liver disorder: For instance, fibrosis complicates both hepatitis C viral (HCV) liver disease and lung silicosis.698,699 In HCV liver disease modeling, miR-192 was identified as a regulator of TGF-β1, which influences the transdifferentiation of hepatic stellate cells into myofibroblasts, contributing to liver fibrosis.650 Exosomes loaded with miR-192 induced this fibrogenic state in hepatic stellate cells, while those containing anti-miR-192 reversed the process.