A recent study in a DMD mouse model demonstrated that hiPSC-derived myogenic precursors expressing conditional PAX7, a chromatin remodeling factor, were sufficient to restore dystrophin expression and improve force generation.779 Following intramuscular transplantation, these hiPSC-derived myogenic precursors successfully engrafted, integrated into the muscle satellite cell pool, and persisted for half of the animals’ lifespan, highlighting the feasibility and potential of iPSC-based treatments for DMD. The gene discussed is PAX7; the disease is Duchenne muscular dystrophy.