YAP1 and hereditary disease: These forces are converted into biochemical signals that regulate essential processes such as homeostasis, proliferation, compression, extrusion, and gene expression—notably through pathways like HIPPO signaling, which involves transcription factors YAP, TAZ, and YKI.37,38 Disruptions in ECM structure—often due to genetic mutations in collagen genes—can lead to a range of hereditary diseases: