In a landmark study, researchers demonstrated that the pioneer transcription factor Ascl1, when combined with Brn2 and Myt1l—collectively known as the Ascl1, Brn2, and Myt1l (ABM) cocktail—could reprogram MEFs into induced neurons (iNs).685 These iNs exhibited key neuronal features, including action potentials, synapse formation, and contractility, making them valuable tools for modeling neurological diseases and screening potential therapeutics. The gene discussed is POU3F2; the disease is nervous system disorder.