Among UK Biobank participants with valid genotyping data, homozygosity for the C allele of rs12608932 in UNC13A (n = 60 581/485 114) was associated with higher risk of ALS, FTD and the combined outcome of ALS or any-cause dementia, compared with other genotypes [ALS: Plog-rank < 0.001, HR = 1.81 (1.50–2.19); FTD: Plog-rank = 0.002, HR = 1.58 (1.18–2.13); ALS or dementia: Plog-rank = 0.007, HR = 1.08 (1.02–1.15); Fig. 3 and Supplementary Tables 8 and 9]. This evidence concerns the gene UNC13A and amyotrophic lateral sclerosis.