GRB10 and Silver-Russell syndrome: In humans, genome-wide association studies (GWAS) show GRB10 is associated with type 2 diabetes [19], and GRB10 copy number variation is associated with Silver Russell Syndrome [20], a rare growth disorder typically characterised by intrauterine growth restriction, low birth weight for gestational age, hypoglycemia, and poor muscle development in childhood, with an increased risk of cardiometabolic disorders in adulthood.